Citation :

Diana Ly-Liu, Ana Andreu, Ellen O´Riordan, Domingo Ly-Pen, "Urticaria Multiforme: 2 Case Reports and Literature Review," International Journal of Medical Science, vol. 13, no. 1, pp. 11-14, 2026. Crossref, https://doi.org/10.14445/IJMS-V13I1P102

Abstract

Introduction: Urticaria Multiforme is a self-limited, benign dermatological disease, mainly in children (usually between 4 months and 6 years old), that can be and that should be diagnosed in a primary care setting. Case report: Two cases of Urticaria Multiforme, a very specific skin rash, almost pathognomonic, are presented. The general condition of the child is excellent; the lesions can be itchy and may have some flu-like symptoms. Usually, there are no other systemic symptoms. Laboratory tests are not helpful in Urticaria Multiforme diagnosis. Conclusion: General practitioners can accurately diagnose Urticaria Multiforme based on the clinical history and physical examination. This will avoid emergency departments overloading, family stress, and unnecessary tests.

Keywords

Urticaria Multiforme.

References

1. Diana Ly-Liu et al., “A Very Frightening But Not Dangerous Rash in Children,” Irish Medical Journal, vol. 118, no. 1, pp. 1-6, 2025.
   [Google Scholar] [Publisher Link]
2. Jason J. Emer et al., “Urticaria Multiforme,” The Journal of Clinical and Aesthetic Dermatology, vol. 6, no. 3, pp. 34-39, 2013.
   [Google Scholar] [Publisher Link]  
3. Maria Claudia Alves Luce et al., “Urticaria Multiforme: A Case Report in an Infant,” Brazilian Annals of Dermatology, vol. 94, no. 5, pp. 628-630, 2019.
   [CrossRef] [Google Scholar] [Publisher Link]
4. L. Sempau et al., “Urticaria Multiforme: A Report of 5 Cases and a Review of the Literatura,” Actas Dermo-Sifiliográficas, vol. 107, no. 1, pp. e1-e5, 2016.
   [CrossRef] [Google Scholar] [Publisher Link]  
5. Mariana Barros et al., “Urticaria Multiforme: A Benign Frightening Rash,” BMJ Case Reports, vol. 14, pp. 1-2, 2021.
   [CrossRef] [Google Scholar] [Publisher Link]  
6. Danielle M. Jones, Adrianna E. Sosa, Vini Vijayan, “Urticaria Multiforme,” The Journal od Pediatrics, vol. 257, 2023.
   [CrossRef] [Google Scholar] [Publisher Link]  
7. Lourds Tamayo-Sanchez, Ramon Ruiz-Maldonado, and Amelia Laterza, “Acute Annular Urticaria in Infants and Children,“ Pediatric Dermatology, vol. 14, pp. 231-234, 1997.
   [CrossRef] [Google Scholar] [Publisher Link]